Also, this only works with XP and above, as it uses GDI+. You might be able to get it working if you are running an earlier version if you install the GDI+ Dll from Microsoft, but I'm not familiar with that.
Take a look at the screenshot below. I've written a simple desktop item launcher using a PNG skin based on the one that comes with a program called Launchy. Of course, you could use any PNG you want, so long as it has an alpha channel. That drop shadow is not the result of a gui effect in Vista - this is running in XP, and the drop shadow is defined in the PNG itself, and applied to the GUI. Imagine the possibilities. Goodbye ugly Regions, hello 32 bit Alpha Transparency.
All credit goes to PaulIA, I'm just the messenger.
Update (5/28/08): I've re-uploaded the demo with GaryFrosts fixes for making this work with AutoIt v126.96.36.199. Thanks Gary!
Edited by lod3n, 28 May 2008 - 11:42 PM.