In a recent discussion, it was found (with AdmiralAlkex’s help) that having DWM enabled caused a massive performance hit (factor of 1,000) when using PixelGetColor. I have only used the _GDIPlus_BitmapLockBits method which according to this example is 20x faster than the "GetPixel" method. Initially I was happy to accept this claim on face value, but after the above discussion I was not so sure. So I made this little script to compare the two methods. The results are highly sensitive to cal