My originaly script where I was noticing this issue was quite long, so I trimmed it down considerably (93 lines to 5) to show the example issue. From what I've noticed in related topics, it's never really been solved (at least from my searches), and it unfortunately seems to not show up on all machines. Description: It seems that when using GUICtrlCreatePic() alongside GuiSetBkColor() the embedded image will get transparent artifacts. It seems as though it's light colors only - as to what color