you probably do not have to do that see below. I installed CEF test app on my PC and below works perfectly also with SimpleSpy Test 1. Start chrome 2. Enter Chrome://accessibility in addressbar and make sure its off 3. Start the attached script 4. Open new tab, you should see a message from AutoIT that event was send and handshake back was send 5. Go back to chrome://accessibility and refresh 6. Accessibility is now on As CEF is based on chromium it should respond similar in the handshake   Work