Disable IE ActiveScripting For a website While IE is in use..??

[cypher175]

im using AutoIts IE functions to navigate to websites and do certain tasks, but I want to selectively turn On & Off IE's ActiveScripting For a website While IE is still in use..??

This RegKey seems to Disable ActiveScripting.. but if the key is written to the Registry while IE is still in use it doesn't seem to get enabled at all until IE is restarted..

RegWrite("HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Internet Settings\Zones\3", "1400", "REG_DWORD", "3")

Does anyone know of any other way to selectively turn On & Off IE's ActiveScripting For a website While IE is still in use..??