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Hello, Please look at this GUI: #include-once ; -- Created with ISN Form Studio 2 for ISN AutoIt Studio -- ; #include <GUIConstantsEx.au3> #include <WindowsConstants.au3> #Include <GuiButton.au3> #include <GuiListView.au3> Global $test = GUICreate("test",283,120,-1,-1,-1,-1) GUISetBkColor(0xFFFFFF,$test) $hListMyList = GUICtrlCreatelistview("My List",7,4,269,65,-1,512) $hButtonAlwaysEnabled = GUICtrlCreateButton("Always Enabled",20,80,100,30,-1,-1) $hButtonEnabled = GUICtrlCreateButton("Enabled",160,80,100,30,-1,-1) $hListViewItemMyItem = GUICtrlCreateListViewItem("My List Item", $hListMyList) GUISetState() While True $nMsg = GUIGetMsg() Switch $nMsg Case $GUI_EVENT_CLOSE Exit EndSwitch WEnd I want $hButtonEnabled disabled when a ListViewItem is not selected. I tried inserting a custom function in the while loop but it didn't work that well (button was flickering & high memory usage) I think its not possible to do in AutoIt AutoIt is awsome! If you know to do such thing, please post it here , TD P.S Will be greatly appreciated cause its impossible for me to do