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Dear all, something very strange happened. I work in a laboratory in which we run software specific for some chemical analyses. I have the same software (albeit with different versions) running on different machines. I have AutoIt installed on all of them, and complement the software using AutoIt for some simple tasks. Today, I was trying to adapt a script that worked on another machine on this one, and it did not work. I investigated further and found that it is a software specific issue, that is, the script would work with a different software (like notepad, for example), but not with the specific software (by the way, its name is Isodat). Even a simple mouse click will not work. Some scenarios: 1) opt("WinTitleMatchMode",1) WinActivate("Isodat Acquisition") Sleep(1000) MouseClick("left",807,495,2) The above does not work. Now, if I replace WinActivate("Isodat Acquisition") with, for example, WinActivate("Untitled"), this being for Notepad, it will work. 2) MouseClick("left",807,495,2) If I simply try a mouse click, and the Isodat window is the target of the click, it will not work. But if it is any other window it will (as fas as I tried). The computer with these strange issues is the only one connected to the internet, and have been automatically updated regularly. The others, in contrast, have almost never been updated. The problematic one is using Windows 7 32bit, one of the others also uses the same OS and the third one goes on XP. I also believe this issue was not happening some months ago when I tried AutoIt on the problematic computer. I suspect something came in an windows update that may have altered the way AutoIt access some programs. Does anything have a clue of anything in this sense? Is there anything that can be done? Any comment is appreciated. Thank you, Matheus